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解析Iduron糖胺聚糖的一般生物學作用
發(fā)布時間： 2022-01-20 點擊次數： 1177次Iduron糖胺聚糖是長線性多糖，由重復的二糖單元（即兩個糖單元）組成。重復的二糖單元由一個糖醛糖和一個氨基糖組成，但角質素除外，在該蛋白中，糖醛酸是半乳糖。由于GAG具有高極性并吸引水，因此它們在體內用作潤滑劑或減震器。它的生產：Iduron糖胺聚糖的分子量，二糖結構硫酸化差異很大。這是因為GAG合成不是像蛋白質或核酸那樣由模板驅動，而是通過加工酶不斷地改變。基于核心二糖結構，GAG分為四類。肝素/硫酸乙酰肝素（HSGAGs）和硫酸軟骨素/硫酸皮膚素（CSGAGs）是在高爾基體中合成的，其中粗糙的內質網中形成的蛋白質核心被O-糖基化后的糖基轉移酶通過糖基轉移酶形成蛋白聚糖而被修飾。硫酸角質素可以通過蛋白聚糖的N-聯糖基化或O-聯糖基化來修飾核心蛋白。GAG的第四類，透明質酸 通過完整的膜合酶合成β-內酰胺酶，該酶立即分泌動態(tài)拉長的二糖鏈。Iduron糖胺聚糖的一般生物學作用：1、由于糖胺聚糖的親水性強，對保持疏松結締組織中的水分有重要意義；2、糖胺聚糖是多價陰離子，對K+、Na+、Ca2+、Mg2+等有較大的親和力，因此能調節(jié)這些離子在組織中的分布；3、糖胺聚糖，主要是透明質酸有很大的粘滯性，附在關節(jié)面上具有潤滑和保護作用；4、有促進創(chuàng)傷愈合的作用。
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